There are multiple diseases in which specific classes of anti-hypertensive medications have been shown to reduce mortality in some trials. Unlike prior guidelines, the JNC 8 gives specific recommendations for hypertension management in the context of some diseases (diabetes and kidney disease) but not others (coronary artery disease or congestive heart failure). The patient-centered practitioner needs to be aware off these diseases and potentially compelling indications to use specific medications. What are the compelling indications? Please take a moment to reflect and consider this question. There are several possible answers.

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